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Mixer affiliates
Shanghai Hanhong chemical technology co., LTD. Is one of the core

members, said han hong enterprise, founded in 2003, the company's

business includes research and development, reagents and custom

synthesis business. The company has a group of senior research

and development and production management personnel; The research

and development center in college construction, construction of

the pilot plant in jiangsu, reactor reached more than 200 sets of

reaction volume range from 10-5000 - l l.
Binhai said Hanhong biochemical co., LTD is one of the core

members, said han hong enterprise was established in 2005, the

production of fine and specialty chemicals, leading edge products

for unnatural amino acids, protected amino acids, chiral

intermediates and heterocyclic block production. It is located in

jiangsu yancheng coastal chemical industry park (one of China's

famous chemical industrial park). Company covers an area of 35000

square meters, there are four 82 - meter multi-function synthesis

workshop, a pilot plant, a sewage pretreatment workshop and

laboratory. Company at present, 80 employees, has more than 40

sets of reactor, volume 50 l to 8000 l, HPLC, GC, HPCE etc.

Various analytical instruments.
Other associated company, the company in shandong, shanxi,

shijiazhuang has the technology investment and four joint

production enterprises, mainly engaged in chiral reagents,

pharmaceutical intermediates, nucleoside products production.
Relying on the company's research and development strength and

production unit, said han hong enterprises can according to

customer requirements, customized production of fine chemical

products from grams to tons of fine chemical products.

Polypeptide custom synthesis
Hanhong chemical with solid-phase synthesis and core technology,

liquid phase synthesis of the peptides and with the advantages of

its own protection amino acids, so can give customers to provide

quality and cheap custom peptide synthesis business, is China's

main custom peptide synthesis.

The custom synthesis of DNA, RNA
Hanhong chemical in their production nucleoside, on the basis of

the phosphoryl according to monomer, combined with our ability to

solid phase synthesis, can provide customers with different size

of DNA, RNA, custom synthesis business. Low prices, quality and

fast is our goal.

The custom synthesis of organic compounds
Our company owns more than 60 staff in organic synthesis, 15 of

organic synthesis laboratory, there are two multi-function

workshop, can provide customers both at home and abroad from

grams to kilograms to tonnage custom synthesis product. Custom

synthesis is one of our main business direction.

Company profile/Companyintroduction
Our company's business includes three blocks: research and

development with chemicals, fine and specialty chemicals, custom

synthesis. He hong's core competence is a senior ORGANIC

synthesis block (ADVANCED ORGANIC BUILDING BLOCKS) production.

Hanhong has the advantage of amino acids, peptides, nucleotide,

production technology, said han hong through technical

investment, joint production holding companies all over the

country set up have four, six joint production enterprises, and

establish the enterprise one. Company engaged in class from grams

to kilograms, the tonnage of senior ORGANIC synthesis block

(ADVANCED ORGANIC BUILDING BLOCKS) production, advantage product

is a natural amino acid (4 production lines, 200 tons/year),

protected amino acids (three production lines, 50 tons/year),

peptides (article 2000 peptide/month), nucleoside and nucleotide

(3 production lines, 80 tons/year), chiral separation agents (2

production lines, 300 tons/year) and some of the heterocyclic

intermediates (2 production lines, 150 tons/year).

News
The company patent authorized acylation of immobilized enzyme

technology. Application (patent no. : 200910047876.0
In this paper,
The invention discloses a kind of preparation methods of

immobilized amine acylation enzyme, it contains the following

steps: in the water, 60-90 ℃ dissolve immobilized material

(carrageenan and gelatin), cooled to 40-60 ℃, add amide acylation

enzyme, mixed evenly, and then the mixture flow to the

temperature of 20-35 ℃ in the organic solvent, stirring, particle

filter, adding the particles to KCl in aqueous solution, curing,

can produce amino acylation enzyme immobilization, among them,

described the KCl contains glutaraldehyde in aqueous solution.

The present invention also made public by its amino acylation of

immobilized enzyme and its application. The preparation method of

the invention can effectively reduce the freezing point of

immobilized materials, and
Amino acylation of immobilized enzyme is granule, good

flowability, can effective convenient split optical activity of

amino acids.

Companies to adopt new technology production FMOC TRP (BOC) - OH

series products
Advanced foam extinguishing system put into use
Mr Ma Shizhong company won the first prize in Shanghai science

and technology progress
Enzymatic production of natural amino acid project won the first

prize of Shanghai science and technology progress
Simmons - Smith reaction
My company's booth no. : 2014 CPHI Shanghai W3B89. Show time:

June 26-28, 2014
The 70th B3R09 API exhibition booths, and on April 25, 2013-27,

wuhan international exhibition center
My company's booth no. : 2013 CPHI Shanghai E5D06. Show time:

June 25 to 27, 2013
Company of preparation methods of immobilized amine acylation

enzyme patent authorized
Company profile
Hanhong reagent
Fine and specialty chemicals
The custom synthesis
Companies use penicillin acylation enzyme on large-scale split

BETA - amino acids
Company of enzyme catalysis process new reactor to obtain the

national patent

The advantage of Hanhong:Hanhong high-end chemical reagent is

introduced.
Hanhong in unnatural amino acids, protected amino acids,

peptides, nucleotides, chiral reagents .such as development and

production has nearly 10 years of history, the kinds of
the products reached more than ten thousand, the scale of

production from grams to
kilograms, they constitutes the core foundation of he hong

reagent. In recent years, said
han hong to further expand the size of the reagent production,

resource integration and to
strengthen the domestic suppliers, varieties and expand to the

advanced organic building
blocks and organic short reagent, can supply varieties reached

more than 20000.
Staff: at present, said han hong has nine reagent synthesis lab

specializes in BULDING
BLOCKS production (laboratory four unnatural amino acids and

protect amino acids,
polypeptide laboratory 1, chiral reagent laboratory 1, BUILDING

three BLOCKS laboratory).
A total of nearly 60 person team of reagent production.
Facilities: laboratory reagent synthesis area of 2000 square

meters, in addition reagent
workshop of 1000 square meters of form a complete set of 50 l -

200 l of small equipment
engaged in the reagent production.
Mode:
Hanhong company laboratory or synthetic reagent workshop -

refining - analysis - packing -
reagent products; External resources integration - purchased

reagents raw material - - refining - analysis - packing - reagent

products; In pieces he hon advantages of high-end chemical

reagent (Hanhong) category. natural amino acid and its

derivatives, protect amino acid series, dipeptide and ripeptide,

chiral separation and chiral reagents in total about 12000

varieties, their
synthesis, for hanhong company basically is hanhong reagents at

the core of the product,
has the absolute cost advantages and technological advantages.

And reagents in organic
synthesis, heterocyclic block, said han hong part of their

production, the other part is
hanhong resources integration, namely, buy from local suppliers,

inspection, refined,
testing and packaging in the form of production.

Hanhong has the advantage of the fine and specialty chemicals.

Hanhong is fine and specialty chemicals producer, is also fine

and specialty chemicals traders and service providers. Hanhong`s

core advantage is a factory, has a professional technical team,

so their production varieties and trade varieties, said han hong

scheme can provide professional technology and service, resolve

customer about product quality and technical requirements, this

is John hong trading company is very different with other place.
When hanhong in the fine and specialty chemicals production has

the core technology advantages:
The synthesis and resolution of the natural amino acid;
(2) to protect the synthesis of amino acids;
(3) short peptide of liquid phase synthetic technologies and

solid-phase synthesis of peptides.
(4) of natural nucleoside synthesis technology;
(5) chiral separation agents and the synthesis of chiral BUILDING

BLOCKS;
6 senior organic block of green synthesis technology;
He hong as a trader, has the following advantage of professional

technology and service plan:
1) hanhong knows product manufacturing process, can give

customers process route, process cost accounting and process

control points data, can according to the characteristics of the

needs of customers to assist manufacturers reasonable adjustment

process according to customer requirements, for the manufacturers

to provide technical services;
(2) hanhong factory owns advanced analysis and test instrument,

is ISO9001 enterprise, the ability to have a good QA and QC team,

so no matter he hong factory products or trade, said han hong can

carry on the rigorous analysis of the quality of product, can

also according to customer requirements for the QA process

control. Can also assist cooperation manufacturers to improve QA

and QC management.
(3) hanhong owns organic synthesis laboratory and organic

synthesis team, so you can accept custom synthesis business. When

a project, first of all done in the laboratory test and pilot

test, process is finished, a situation is directly in the

company's production base, another is in outsourcing production

cooperation company.
(4) hanhong company engaged in the fine and specialty chemicals

has been more than 10 years, be familiar with the domestic

production situation of fine and specialty chemicals industry,

familiar with import and export business, thus can fight for a

more reasonable price to customers and interests.

Polypeptide custom
The rigorous work attitude, high quality source of raw materials,

the synthesis of rich experience, strong production and research

and development, and quality management experience for many

years, adumbrative we will provide customers with the most

excellent synthesis service. Shanghai hanhong chemical technology

co., LTD. As one of the earliest companies involved in peptide

synthesis and the research and development, we start from peptide

raw materials, in the domestic customers to provide more high

quality peptide raw materials at the same time, also in our

peptides to further development. Now, we are offering a peptide

products have been widely used in the world of colleges and

universities, scientific research institutions of experimental

studies. And, we also offer domestic drug manufacturers peptide

API. Company directly engaged in peptide synthesis of front-line

staff increased to 30 people, and a high performance liquid

chromatography (HPLC) purification team composed of more than 20

people.
Company in addition to the synthetic technology, also USES the

automatic peptide synthesis equipment specializing in the

production of mg, more research and development of series of

varieties of peptide products to meet customer needs. We have

developed different solid phase synthesis method to meet the

demand of commercial level polypeptide.
Products and services:
Normal linear peptide: chain length to 140 amino acids, mg to

grams, purity can reach 99%;
Simple modification peptide: free N acetylation, end amidation;
Complex modifying peptides: fat peptide, peptide phosphate (Ser,

Thr, Tyr), cyclic peptide (amide, disulfide bond), fluorescent

marker peptides (FAM, FITC), BIOTIN labeling peptides (BIOTIN),

compound antigen peptide (MAP), etc.;
Protein crosslinking: KLH, BSA and OVA;
Contain special amino acid peptide: D amino acid and various

kinds of amino acid derivatives;
Scope: different purity coarse peptide, > 70% and > 80% and > 90%

and > 95% and > 98% and > 99%;

Amino acids
Chinese pharmacopoeia 2005 edition contains varieties: propylene

ammonia gonadorelin acetate
Chinese pharmacopoeia 2005 edition contains varieties: valine
Chinese pharmacopoeia 2005 edition contains varieties: acetic

acid lysine
Chinese pharmacopoeia 2005 edition contains varieties: arginine
The Chinese pharmacopoeia 2005 edition contains varieties:

tyrosine
Chinese pharmacopoeia 2005 edition contains varieties: proline
The Chinese pharmacopoeia 2005 edition contains varieties:

cystine
Chinese pharmacopoeia 2005 edition contains varieties: arginine

hydrochloride
Chinese pharmacopoeia 2005 edition contains varieties: lysine

hydrochloride
Chinese pharmacopoeia 2005 edition contains varieties: histidine

hydrochloride
Chinese pharmacopoeia 2005 edition contains varieties: cysteine

hydrochloride
The Chinese pharmacopoeia 2005 edition contains varieties:

leucine
The Chinese pharmacopoeia 2005 edition contains varieties:

histidine
Chinese pharmacopoeia 2005 edition contains varieties: monosodium

glutamate
The Chinese pharmacopoeia 2005 edition contains varieties:

glutamic acid