Clinical Oncology News Vosaroxin is a topoisomerase II inhibitor that is a first-in-class anticancer quinolone derivative being developed by Sunesis. Unlike most other...
Wall Street Pulse Vosaroxin is a anti-cancer quinolone derivative (AQD). AQDs have been shown to mediate anti-tumor activity by targeting mammalian topoisomerase II, an enzyme critical for cell replication. The Company owns worldwide development and commercialization ... and more »
Medscape Purpose of review Uncertainties exist regarding the optimal treatment for vancomycin-resistant enterococcal (VRE) bloodstream infections, particularly in settings in which ampicillin cannot be used. Recent findings Quinupristin-dalfopristin, linezolid ...
DailyTech Gram negative bacteria have increasingly developed proteins that bond to manmade quinolone antibiotics, blocking their effects. Worse, Enterobacteria possess a β-lactamase enzymes that use serine active sites (among others) to cleave most β-lactam ... and more »
Seeking Alpha (registration) Subsequent to the year-end, we licensed into the Canadian rights to Ozenoxacin, a topical treatment for adult and pediatric patients with impetigo, from Ferrer, This is a topical non-fluorinated quinolone antibiotic design to provide the efficacy of a ... and more »
ModernMedicine Dr Goldstein GoldsteinPresident Obama's recent proposal to nearly double funding for antibiotic resistance programs to $1.2 billion in the 2016 federal budget confirms that the battle against “superbugs” is indeed moving up the government agenda ...
Seeking Alpha (registration) Ozenoxacin is a next-generation non-fluorinated quinolone being developed to combat resistance of certain bacteria to earlier-generation quinolone and fluoroquinolone antibiotics such as moxifloxacin, ciprofloxacin, and levofloxacin. Quinolones and ... and more »
Monthly Prescribing Reference Quinolones and fluoroquinolones are effective broad-spectrum antibiotics that are used to treat numerous infections; however, concerns about possible teratogenic effects seen in animal studies have limited their use during pregnancy. In a study ...
WCNC Quinolone Vigilance Foundation strongly urges the FDA to add stronger la...nguage and add the risks of Mitochondrial Toxicity and Psychiatric Effects on top of the current warnings of tendon rupture and peripheral neuropathy. A comprehensive list of ... and more »
East Brunswick Sentinel For patients who have penicillin allergies, trimethoprim-sulfamethoxazole (Bactrim), azithromycin (five days), clarithromycin, or a quinolone drug (levofloxacin or moxifloxacin) can be used. Cultures taken from the nose prior to initiating antibiotic ...
